Raymond Vanholder Selected Research

4-cresol (p-cresol)

12/2017	p-Cresyl glucuronide is a major metabolite of p-cresol in mouse: in contrast to p-cresyl sulphate, p-cresyl glucuronide fails to promote insulin resistance.
1/2013	p-Cresyl sulfate promotes insulin resistance associated with CKD.
2/2004	The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair.
10/2003	Comparative kinetics of the uremic toxin p-cresol versus creatinine in rats with and without renal failure.
7/2003	Urinary excretion of the uraemic toxin p-cresol in the rat: contribution of glucuronidation to its metabolization.
3/2003	Toxicity of free p-cresol: a prospective and cross-sectional analysis.
12/2002	P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines.

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Raymond Vanholder Research Topics

Disease

57	Chronic Renal Insufficiency 09/2021 - 01/2005
30	Acute Kidney Injury (Acute Renal Failure) 01/2022 - 11/2002
26	Inflammation (Inflammations) 01/2022 - 09/2002
23	Renal Insufficiency (Renal Failure) 07/2021 - 01/2002
21	Chronic Kidney Failure (Chronic Renal Failure) 12/2018 - 01/2002
16	Kidney Diseases (Kidney Disease) 04/2022 - 11/2010
12	Sepsis (Septicemia) 01/2016 - 01/2002
11	Cardiovascular Diseases (Cardiovascular Disease) 01/2017 - 01/2007
11	Uremia 09/2015 - 12/2002
9	Insulin Resistance 08/2021 - 11/2007
9	Hypertension (High Blood Pressure) 01/2021 - 11/2008
9	Critical Illness (Critically Ill) 08/2016 - 03/2002
8	Infections 01/2016 - 03/2003
5	Vascular Diseases (Vascular Disease) 02/2020 - 07/2009
5	Malnutrition (Nutritional Deficiencies) 01/2020 - 09/2002
5	Bone Diseases (Bone Disease) 01/2017 - 01/2002
5	Fibrosis (Cirrhosis) 01/2015 - 01/2010
4	Neoplasms (Cancer) 01/2017 - 12/2008
4	Wounds and Injuries (Trauma) 02/2004 - 01/2002
3	Arteriovenous Fistula 12/2020 - 01/2019
3	Anemia 06/2020 - 02/2005
3	Hypotension (Low Blood Pressure) 01/2018 - 04/2003
3	Proteinuria 06/2016 - 12/2008
3	Albuminuria 08/2015 - 12/2008
3	Vascular Calcification 07/2015 - 11/2005
3	Chronic Kidney Disease-Mineral and Bone Disorder (Renal Rickets) 07/2014 - 01/2002
3	Fabry Disease (Fabry's Disease) 03/2013 - 01/2008
3	Thrombosis (Thrombus) 01/2013 - 05/2005
3	Type 2 Diabetes Mellitus (MODY) 12/2012 - 09/2010
3	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2006 - 01/2002
3	Disseminated Intravascular Coagulation 03/2006 - 01/2002
3	Peritonitis 08/2003 - 11/2002
2	Acidosis 01/2018 - 08/2014
2	Hemorrhage 01/2018 - 01/2011
2	Glucose Intolerance 08/2017 - 05/2013
2	Hyponatremia 07/2017 - 12/2014
2	Diabetes Mellitus 01/2017 - 12/2014
2	IGA Glomerulonephritis (IGA Nephropathy) 06/2016 - 05/2013
2	Purpura 06/2016 - 05/2013
2	Nephritis 06/2016 - 05/2013
2	Heart Failure 11/2015 - 02/2009

Drug/Important Bio-Agent (IBA)

23	Uremic ToxinsIBA 07/2021 - 09/2002
20	Biomarkers (Surrogate Marker)IBA 06/2021 - 04/2007
20	Proteins (Proteins, Gene)FDA Link 01/2021 - 09/2002
14	CreatinineIBA 06/2016 - 01/2002
9	IndicanIBA 09/2021 - 02/2004
9	Urea (Carbamide)FDA LinkGeneric 06/2021 - 04/2005
8	MineralsIBA 08/2021 - 11/2005
8	Dialysis SolutionsIBA 10/2013 - 01/2002
7	SodiumIBA 01/2018 - 12/2009
7	4-cresol (p-cresol)IBA 12/2017 - 12/2002
7	AlbuminsIBA 04/2015 - 09/2002
7	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 12/2008
6	Edetic Acid (EDTA)FDA Link 12/2021 - 06/2015
6	Sulfates (Sulfates, Inorganic)IBA 01/2021 - 01/2012
6	MagnesiumIBA 08/2017 - 08/2011
5	ElectrolytesIBA 01/2022 - 12/2008
5	CalciumIBA 08/2010 - 05/2003
4	LipidsIBA 01/2021 - 01/2013
4	Biological ProductsIBA 01/2021 - 07/2009
4	Insulin (Novolin)FDA Link 12/2017 - 12/2008
4	Erythropoietin FDA Link 04/2017 - 02/2005
4	symmetric dimethylarginineIBA 10/2016 - 05/2009
4	Indicators and Reagents (Reagents)IBA 01/2008 - 11/2002
3	IronIBA 06/2020 - 01/2002
3	GlucuronidesIBA 01/2020 - 01/2014
3	DiureticsIBA 01/2018 - 05/2004
3	AngiotensinsIBA 04/2017 - 02/2007
3	Peptides (Polypeptides)IBA 01/2016 - 02/2007
3	Cystatin CIBA 03/2015 - 06/2011
3	Lipocalin-2IBA 02/2015 - 02/2012
3	Phosphates (Orthophosphate)IBA 11/2014 - 07/2009
3	SaltsIBA 03/2014 - 11/2008
3	Interleukin-6 (Interleukin 6)IBA 02/2013 - 03/2010
3	Sevelamer (RenaGel)FDA Link 08/2010 - 11/2005
3	EnzymesIBA 01/2010 - 02/2007
2	AcidsIBA 01/2022 - 11/2010
2	HematinicsIBA 06/2020 - 12/2018
2	indoleacetic acid (indole acetic acid)IBA 01/2020 - 05/2003
2	ProteomeIBA 12/2017 - 11/2015
2	AldosteroneIBA 04/2017 - 01/2017
2	ReninIBA 04/2017 - 01/2017
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 11/2016 - 01/2012
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016 - 03/2012
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 01/2016 - 05/2009
2	Antihypertensive Agents (Antihypertensives)IBA 10/2015 - 03/2014
2	Advanced Glycation End ProductsIBA 08/2015 - 11/2004
2	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2015 - 01/2012

Therapy/Procedure

16	Renal Dialysis (Hemodialysis) 07/2020 - 01/2002
15	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2018 - 01/2002
11	Transplantation 06/2021 - 01/2010
11	Therapeutics 01/2021 - 10/2004
9	Peritoneal Dialysis 07/2021 - 11/2002
8	Kidney Transplantation 04/2022 - 12/2004
7	Catheters 02/2020 - 05/2005
3	Postoperative Care 12/2020 - 01/2019
3	Resuscitation 07/2020 - 12/2008
3	Continuous Ambulatory Peritoneal Dialysis (CAPD) 04/2007 - 11/2002
2	Critical Care (Surgical Intensive Care) 07/2017 - 01/2002
2	Hemodiafiltration 01/2017 - 08/2006